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You have been diagnosed with a chronic health condition. Your genetic information will help you determine which genes or biochemical pathways were altered to result in that health condition. Getting to the root cause, will help facilitate recovery by tailoring any treatment plans and lifestyle changes your Doctor recommends specifically to your body.

Several members of your family live with one or several chronic health issues. Genetic information will help your family uncover the inherited Gene sequence patterns that contribute to the chronic illnesses plaguing them.

You plan to have a baby: Research is implicating certain genetic mutations in a ... ..more

By Carol Savage
"Is it possible for people to be low in L-Methyl Folate [5-MTHF] even if they do NOT have single nucleotide polymorphisms affecting the MTHFR enzyme?"

The answer is... YES.

DIET
A person can have terrible nutrition. Someone who doesn't eat anything green. Someone who never eats beans. A poor diet low in DiHydroFolate [DHF] can cause there to be insufficient L-Methyl Folate.

MEDICATIONS
This includes thousands of people on coumadin [warfarin] who avoid eating greens and people with Rheumatoid Arthritis [RA] who have been given Methotrexate. Methotrexate blocks the enzyme that converts DHF into TetraHydroFoalte [THF ... ..more

By Carol Savage
"Is it possible for people to be low in L-Methyl Folate [5-MTHF] even if they do NOT have single nucleotide polymorphisms affecting the MTHFR enzyme?"

The answer is... YES.

DIET
A person can have terrible nutrition. Someone who doesn't eat anything green. Someone who never eats beans. A poor diet low in DiHydroFolate [DHF] can cause there to be insufficient L-Methyl Folate.

MEDICATIONS
This includes thousands of people on coumadin [warfarin] who avoid eating greens and people with Rheumatoid Arthritis [RA] who have been given Methotrexate. Methotrexate blocks the enzyme that converts DHF into TetraHydroFoalte [THF ... ..more

5 “Healthy” Foods That Aren’t
January 15, 2014 by Erin Ter Beest

In a world of competing health claims, it’s hard to know what foods are really nourishing and health-promoting. Sometimes it’s even hard to tell whether or not something is really food or just a “food-like substance!” While the occasional #junk food isn’t going to kill you (and stressing out about completely avoiding it might actually do more damage than the occasional junk food itself), there are many “health” foods that have made their way into our diets regularly that are doing serious damage to ... ..more

Julie Matthews, Author Nourishing Hope: Benefits range dramatically from child to child. Many parents report that their children make wonderful gains in language when starting a special diet, such as gluten-free casein-free – it may be an increase in words, speaking in sentences, or back and forth conversation. Some children make gains in behavior, a reduction in irritability or tantrums, or less hyperactivity. Other children have improvements in the quality of life, relief of digestive upset, fewer colds and infections, and are happier and healthier. While benefits differ, my experience as a Certified Nutrition Consultant specializing in autism for the past ... ..more

HISTAMINE AND THE GUT By Carol Savage M.D.
Diamine Oxidase (DAO) is the enzyme in the gut responsible for the degradation of HISTAMINE.

Histamine N-MethylTransferase [HNMT] is an enzyme found inside cells so it breaks down histamine within cells. Diamine Oxidase [DAO] is likely “responsible for scavenging extracellular histamine after mediator release.”
Although Diamine Oxidase [DAO] is found everywhere in the body, the bowels are perhaps the most important site of the action of the enzyme DAO.
DAO is synthesized by mature and undamaged enterocytes [gut cells] in the small bowel, so any gut damage would decrease DAO release ... ..more

#Parasympathetic Nervous System “Rest, repair, & digest” or “Type B’s” There are 3 basic #PNS Dominant subtypes: Basic, Extreme, & Inefficient PNS Dominant types.
The following is a summary of the average PNS Dominant type. 
 The parasympathetic nervous system (PNS) works to nourish, heal and regenerate the body. It is anabolic, which means it is concerned with rebuilding the body and storing nutrients. Its’ nerves stimulate the immune system, digestion, and urinary function. These organs include the liver, pancreas, stomach, intestines, kidneys, and bladder.

The parasympathetic nervous system, when activated by rest, relaxation and positive thinking, is essential for the elimination of wastes, emotional wellbeing and healing. When you feel absolutely stuffed and lethargic after a big Thanksgiving dinner, it is your PNS that is most active. 
 
In situations in which we have excessive parasympathetic nervous system dominance, we often find #disorganization , #depression , #apathy , and #lethargy . There may also be a decrease in clarity of thought such as “spaciness” or poor concentration. The #adrenal and #thyroid glands tend to be underactive and sex #hormones such as #estrogen , #progesterone , and #testosterone are abnormally low. There are frequently issues with multiple #allergies and sensitivities #MCS , dry skin, weight gain or a tendency toward #obesity . These are generally the people who go on the same exact “Healthy” diet as their friends or partner yet struggle to lose a few pounds. Meanwhile, everyone one else has lost 10-20 lbs and is back to their regular routine. 



Other signs and symptoms include: frequent hunger, dry/irritated eyes, unexplained sneezing or coughing, #asthma , dizziness (particularly with standing), irregular heart beats or “skipped heart beats”, low blood pressure, and #hypoglycemia as well as increased production of all digestive enzymes and bowel activity, leading to more “stomach rumbling”. #PNS Dominants rarely struggle with #constipation and may have periods of loose or frequent stools. They are also more likely to experience the feeling of being “Tired yet wired,” particularly after eating a simple carbohydrate or sugary snack.

While #SNS Dominants may also struggle with this tired yet wired sensation, it is usually more prominent in PNS Dominance. Incidentally, those who cannot tolerate higher altitudes or the more rapid drops in barometric pressure (weather changes) are more likely the PNS Dominant or “Inefficient Balanced” types as a stronger SNS is required in adjusting to higher altitudes and changing weather patterns. These are the folks who know the weather is going to change before anyone else and often suffer with allergies or headaches. They are also prone to upper #respiratory infections, which may evolve to #bronchitis or #pneumonia . Despite this, they do not tolerate hot weather as well as the other types and prefer colder climates. They are also prone to flushing and may have pinker or darker ears and a “ruddy” complexion.

Nevertheless, when these individuals are well, they can be highly creative and productive and are often slow to anger. They tend to have less interest in “left brain” academics (math or science) and often prefer “right brain” academics (art, music, & lit).

According to Dr. Gonzalez, many Nobel Prize winners in art and literature are PNS Dominants (Hemmingway, Faulkner, & Lewis). PNS Dominants typically avoid confrontational professions and enjoy those, which allow their heightened creative abilities to flourish. And, depending upon where they reside within the PNS axis, many are “foodies” who live to eat rather than simply eating to live, as SNS types tend to do. These folks typically enjoy discussing good restaurants or engaging in discussions about great meals and recipes. They typically gravitate toward meat & potatoes with some veggies usually the root (potatoes, squash, yams) or cruciferous veggies (broccoli, cauliflower, Brussel Sprouts, cabbage). In general, PNS Dominants are more sociable than SNS types. Likewise, they may prefer to remain busy yet tend to avoid exercise. Still, #genetic factors also considerably influence many of these traits.


Finally, PNS Dominants are most likely to develop immune related cancers such as malignant #melanoma , #lymphoma , #sarcoma , and #leukemia . 
 
Food priorities: It is generally helpful to evaluate the foods you crave and how you tolerate each newly introduced food. For instance, after eating meat do you feel better and more clearheaded or are you more anxious, jittery, or depressed? If you’re having a lot of digestive issues, you may want to begin with mostly cooked foods, at least to some degree, in order to reduce the strain on your digestive system. Therefore, it is important to consider whether or not you tolerate raw vs. cooked foods. Those with PNS Dominance favor butter, cream, meat, and potatoes as well as sour flavors. Yet they avoid sweets, although a heavier pastry with butter or cream is acceptable. 
 


Regrettably, many PNS Dominants have been heavily influenced by medical and nutrition experts and eat well outside their nutritional requirements. They may favor heavier, “meat & potato” meals yet eat leaner meats, whole grain carbs, fruits, and vegetables despite not feeling satisfied. While many desire bacon and egg breakfasts, they opt for the lighter fruit, toast, and yogurt fare of the SNS Dominant, thinking this is a “healthier” choice. And, even while they gag at the thought of oatmeal or cream of wheat, they do their best to find a “healthy” compromise. They frequently have a spurt of energy for 30 minutes or so, only to feel tired and lackluster within the space of an hour. Yet, if allowed to eat a thick slice of ham with potatoes, they’ll have the energy they need to work throughout the entire morning.

In fact, many “vegetarian” PNS Dominants feel much more alert and energetic when they start eating animal proteins While they sought out the heavier “allowed” proteins (cheese, eggs, hummus), most never felt satiated. 
 
For the PNS Dominant, eating meat is not “morally inferior”; it is essential for their health and survival Ultimately, each person should consume the most healthful foods for their metabolic make up. Though SNS Dominants require mostly vegetarian, raw foods, for greatest health, those who are PNS Dominant require fattier, red meats. They are hardwired to function well on the wholesome, omega 3 fats & #glutamate found in grass fed meats. Besides, most will develop a multitude of health problems if they adopt the SNS Dominant’s diet. 
 
For those with concerns regarding #sulfur , while foods such as #broccoli & #cauliflower contain a fair amount of sulfur ... ..more

Annonymous

What are Free Radicals & Oxidants ?

  4 years, 11 months ago

We frequently hear terms such as free radicals, #oxidative stress, and #antioxidants yet what exactly do these mean? Normally, a healthy cell has paired electrons—one that is positive and another that is negative.

Free radicals are molecules without positive electrons and are created whenever there is oxidation, AKA oxidative stress. This is really just a normal part of the everyday fallout of metabolism and by itself, isn’t necessarily a bad thing. Nonetheless, a city overwrought by criminals easily overwhelms the honest and industrious residents. Soon enough, the best and brightest citizens flee to the suburbs while this once ... ..more

#Autonomic #Nervous System Dominance
The autonomic nervous system controls all of the bodily functions that are essential for survival, yet are mostly spontaneous or automatic. Your heart rate, blood pressure, digestion, and hormone production are all under the preprogrammed function of the autonomic nervous system. This critical neurological system is divided into the #parasympathetic and #sympathetic nervous systems. Aside from #genetic and biochemical factors, this division appears to be significant, influencing human conditions such as #depression , #anxiety , #cancer, #heart disease, #allergies , #ADD / #ADHD , #CFS and multiple chemical sensitivity, to name merely a few.


Leading researchers and practitioners have found that ... ..more

For a list of High Histamine foods http://m.ajcn.nutrition.org/.../85/5/1185/T3.expansion.html
#Histamine #Homozygous #MTHFR #Heterozygous #health #23andMe #SNPs #Genes #Methylation #MCAD

 ..more

Julie Matthews, Author Nourishing Hope: Benefits range dramatically from child to child. Many parents report that their children make wonderful gains in language when starting a special diet, such as gluten-free casein-free – it may be an increase in words, speaking in sentences, or back and forth conversation. Some children make gains in behavior, a reduction in irritability or tantrums, or less hyperactivity. Other children have improvements in the quality of life, relief of digestive upset, fewer colds and infections, and are happier and healthier. While benefits differ, my experience as a Certified Nutrition Consultant specializing in autism for the past ... ..more

#Autonomic #Nervous System Dominance
The autonomic nervous system controls all of the bodily functions that are essential for survival, yet are mostly spontaneous or automatic. Your heart rate, blood pressure, digestion, and hormone production are all under the preprogrammed function of the autonomic nervous system. This critical neurological system is divided into the #parasympathetic and #sympathetic nervous systems. Aside from #genetic and biochemical factors, this division appears to be significant, influencing human conditions such as #depression , #anxiety , #cancer, #heart disease, #allergies , #ADD / #ADHD , #CFS and multiple chemical sensitivity, to name merely a few.


Leading researchers and practitioners have found that ... ..more

Annonymous

What is Sympathetic

  4 years, 11 months ago

SNS Dominants, AKA “Type A” – Otherwise known as “Carbo types”, “Slow oxidizers” & “Sympathetic dominant”. This simply means that they slowly break down meals (whole grains, fruits, veggies & lean proteins) in order to obtain the necessary energy required for their more active lifestyles. Food may sit “like a rock” in their guts so that they remain full much longer than they should. They generally have weak appetites (forgetting to eat at times) and a high tolerance for sweets. They are often "type A" personalities who may be dependent on caffeine. When not functioning optimally, they may feel agitated, "wired" or "on ... ..more

Vimeo

Many enzymes are dependent upon Selenium as a helper.
Rec: Selenium #Supplement 200 mcg/day

MERCURY
Selenium gets depleted when mercury levels are high.
One selenium molecule can sequester [grab up] 5-10 molecules of mercury. If Selenium is all bound up with Mercury then it will not be available to assist enzymes for proper thyroid function.

Avoid eating the fatty parts of deep sea fish where the Mercury tends to locate. For example cut away the fatty strip of Sward Fish and do not eat that.

MOST of the conversion of #T4 into #T3 and reverse T3 [rT3] occurs in ... ..more

1) Biopterin/Neopterin: For those with A1298C mutations, #BH4 (also known as tetrahydrobiopterin) levels are typically quite low. This test provides insight to how low these levels are and why. If neopterin levels are high, then I am considering the possibility of a lingering infection, inflammation or chronic immune response that is preventing #biopterin from being formed. Thus, this test provides information not only potentially low biopterin levels but also why they may be low.

If a doctor simply prescribes BH4 without understanding the need to address the inflammation and chronic infections, it is band-aide treatment over a gaping wound ... ..more

Julie Matthews: There is overwhelming scientific support for “diet and nutrition intervention” for ADHD and autism. Many studies indicate that children with autism and ADHD have deficiencies in nutrients such as zinc, iron, fatty acids, and that supplements improved symptoms. There are studies showing benefit with nutritional support for autism and ADHD. There are also studies on B6 and magnesium helping improve symptoms of autism. One study on children with autism showed that a multivitamin-mineral formula improved all areas of autistic symptoms studied including: language, play, sociability, hyperactivity, cognition, eye contact, and more. The aggregate science screams “pay attention to ... ..more

#Parasympathetic Nervous System “Rest, repair, & digest” or “Type B’s” There are 3 basic #PNS Dominant subtypes: Basic, Extreme, & Inefficient PNS Dominant types.
The following is a summary of the average PNS Dominant type. 
 The parasympathetic nervous system (PNS) works to nourish, heal and regenerate the body. It is anabolic, which means it is concerned with rebuilding the body and storing nutrients. Its’ nerves stimulate the immune system, digestion, and urinary function. These organs include the liver, pancreas, stomach, intestines, kidneys, and bladder.

The parasympathetic nervous system, when activated by rest, relaxation and positive thinking, is essential for the elimination of wastes, emotional wellbeing and healing. When you feel absolutely stuffed and lethargic after a big Thanksgiving dinner, it is your PNS that is most active. 
 
In situations in which we have excessive parasympathetic nervous system dominance, we often find #disorganization , #depression , #apathy , and #lethargy . There may also be a decrease in clarity of thought such as “spaciness” or poor concentration. The #adrenal and #thyroid glands tend to be underactive and sex #hormones such as #estrogen , #progesterone , and #testosterone are abnormally low. There are frequently issues with multiple #allergies and sensitivities #MCS , dry skin, weight gain or a tendency toward #obesity . These are generally the people who go on the same exact “Healthy” diet as their friends or partner yet struggle to lose a few pounds. Meanwhile, everyone one else has lost 10-20 lbs and is back to their regular routine. 



Other signs and symptoms include: frequent hunger, dry/irritated eyes, unexplained sneezing or coughing, #asthma , dizziness (particularly with standing), irregular heart beats or “skipped heart beats”, low blood pressure, and #hypoglycemia as well as increased production of all digestive enzymes and bowel activity, leading to more “stomach rumbling”. #PNS Dominants rarely struggle with #constipation and may have periods of loose or frequent stools. They are also more likely to experience the feeling of being “Tired yet wired,” particularly after eating a simple carbohydrate or sugary snack.

While #SNS Dominants may also struggle with this tired yet wired sensation, it is usually more prominent in PNS Dominance. Incidentally, those who cannot tolerate higher altitudes or the more rapid drops in barometric pressure (weather changes) are more likely the PNS Dominant or “Inefficient Balanced” types as a stronger SNS is required in adjusting to higher altitudes and changing weather patterns. These are the folks who know the weather is going to change before anyone else and often suffer with allergies or headaches. They are also prone to upper #respiratory infections, which may evolve to #bronchitis or #pneumonia . Despite this, they do not tolerate hot weather as well as the other types and prefer colder climates. They are also prone to flushing and may have pinker or darker ears and a “ruddy” complexion.

Nevertheless, when these individuals are well, they can be highly creative and productive and are often slow to anger. They tend to have less interest in “left brain” academics (math or science) and often prefer “right brain” academics (art, music, & lit).

According to Dr. Gonzalez, many Nobel Prize winners in art and literature are PNS Dominants (Hemmingway, Faulkner, & Lewis). PNS Dominants typically avoid confrontational professions and enjoy those, which allow their heightened creative abilities to flourish. And, depending upon where they reside within the PNS axis, many are “foodies” who live to eat rather than simply eating to live, as SNS types tend to do. These folks typically enjoy discussing good restaurants or engaging in discussions about great meals and recipes. They typically gravitate toward meat & potatoes with some veggies usually the root (potatoes, squash, yams) or cruciferous veggies (broccoli, cauliflower, Brussel Sprouts, cabbage). In general, PNS Dominants are more sociable than SNS types. Likewise, they may prefer to remain busy yet tend to avoid exercise. Still, #genetic factors also considerably influence many of these traits.


Finally, PNS Dominants are most likely to develop immune related cancers such as malignant #melanoma , #lymphoma , #sarcoma , and #leukemia . 
 
Food priorities: It is generally helpful to evaluate the foods you crave and how you tolerate each newly introduced food. For instance, after eating meat do you feel better and more clearheaded or are you more anxious, jittery, or depressed? If you’re having a lot of digestive issues, you may want to begin with mostly cooked foods, at least to some degree, in order to reduce the strain on your digestive system. Therefore, it is important to consider whether or not you tolerate raw vs. cooked foods. Those with PNS Dominance favor butter, cream, meat, and potatoes as well as sour flavors. Yet they avoid sweets, although a heavier pastry with butter or cream is acceptable. 
 


Regrettably, many PNS Dominants have been heavily influenced by medical and nutrition experts and eat well outside their nutritional requirements. They may favor heavier, “meat & potato” meals yet eat leaner meats, whole grain carbs, fruits, and vegetables despite not feeling satisfied. While many desire bacon and egg breakfasts, they opt for the lighter fruit, toast, and yogurt fare of the SNS Dominant, thinking this is a “healthier” choice. And, even while they gag at the thought of oatmeal or cream of wheat, they do their best to find a “healthy” compromise. They frequently have a spurt of energy for 30 minutes or so, only to feel tired and lackluster within the space of an hour. Yet, if allowed to eat a thick slice of ham with potatoes, they’ll have the energy they need to work throughout the entire morning.

In fact, many “vegetarian” PNS Dominants feel much more alert and energetic when they start eating animal proteins While they sought out the heavier “allowed” proteins (cheese, eggs, hummus), most never felt satiated. 
 
For the PNS Dominant, eating meat is not “morally inferior”; it is essential for their health and survival Ultimately, each person should consume the most healthful foods for their metabolic make up. Though SNS Dominants require mostly vegetarian, raw foods, for greatest health, those who are PNS Dominant require fattier, red meats. They are hardwired to function well on the wholesome, omega 3 fats & #glutamate found in grass fed meats. Besides, most will develop a multitude of health problems if they adopt the SNS Dominant’s diet. 
 
For those with concerns regarding #sulfur , while foods such as #broccoli & #cauliflower contain a fair amount of sulfur ... ..more