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Annonymous

What is MTHFR A1298C Gene Mutation ?

  3 years, 9 months ago

By Helen Janneson Bense

A1298C single nucleotide polymorphism (SNP) affects the enzyme known as 5,10 MethyleneTetraHydroFolate Reductase (MTHFR). This polymorphism involves a down regulation of the MTHFR enzyme, responsible for the backwards reaction of the folate cycle, where 5-methylfolate (5MTHF) is converted into tetrahydrofolate (THF). This reaction is most important for the production of BH4 – tetrahydrobiopterin. Each turn of the folate cycle and conversion of 5MTHF to THF produces 1 molecule of BH4. In heterozygous and homozygous states, enzyme activity will be compromised by
approximately 30% and 70% respectively.

Functions of BH4
Cofactor for all three isotypes of nitric ... ..more

From: http://www.stopthethyroidma...
"As explained well in the revised STTM book, which you should have on hand and bookmarked at the doctors office. The book is in English, Spanish, German and Swedish.

TSH: for diagnosis of hypopituitary, NOT to diagnose or dose your hypothyroidism (unless it’s high). If you allow a doctor to diagnose or dose you by this lab test and range i.e. to say you are normal simply because it’s in range or below 10…you’ll could still be hypothyroid.
Free #T4 and Free #T3 (note the word “free”–important since it measures ... ..more


By Caledonia
1-21-2014

ME/CFS patients are notoriously very sensitive to medicines and supplements. It’s common to have adverse reactions, or to only be able to tolerate small doses.
Newbies are especially prone to taking too large of doses or going too fast. The following explains how to manage such sensitivity.

Start Low and Go Slow

Whenever you start a new medicine or supplement, it is suggested to practice Start Low and Go Slow.

This means starting with very small doses, much less than a normal dose, such as 1/8 of pill. That way, if you're going ... ..more

YouTube

MTHFR C677T Mutation: Basic Protocol by Dr Lynch on February 24, 2012 in C677T MTHFR Mutations
Have one or two copies of the MTHFR C677T mutation? Don’t know what to do?

After working with 100′s of individuals with this defect, I’ve developed a protocol which may help a significant number of people.
I want to make it absolutely clear that while the MTHFR C677T mutation may be common across a number of individuals, the outcome of supplementing with various nutrients can vary tremendously due to other genetic defects, dietary and lifestyle choices and environmental exposures.

Some of ... ..more

What does this process look like when it’s broken? After reading the following, you will be able to envision the implications of defects or mutations. The following is an example of the health problems that might occur.
1. Poor nerve function leads to muscle twitching, numbness, and weakness yet misfires can cause seizures, fatigue, memory loss, word groping, clumsiness (with falls & injuries), and visual or hearing loss in those with MS, CFS/ME, or Autism Spectrum Disorders.

2. Depending on the neuro-talker, imbalances often lead to a variety of disorders including: depression, anxiety, panic attacks, irritability, mood swings, OCD ... ..more

The Energy or Citric Acid Cycle:
The Krebs cycle, also called the citric acid cycle or the “Energy Cycle,” is a series of chemical reactions that convert food (sugar, protein, and fat) into energy (ATP). It is referred to as a cycle since it should always end where it began. This process occurs through three main stages within each cell:

1). Glycolysis, otherwise known as the breakdown of sugar, yields 2 molecules of ATP, 2 molecules of NADH, and two forms of pyruvate (6 forms of currency in all). This is actually a step that takes place before the energy ... ..more

YouTube

1). #MTHFR #A1298C + #Liver & #BH4 support
Start at a few crumbs per day and very gradually, go up over several weeks’ time (generally 4-6 weeks). The goal is 1⁄2 to 1 capsule daily ($54.95/60 caps & $29.95/30 caps). This is whether you have the MTHFR A1298C defect or not.

2). Black Bear Spray or Get B12 Spray
Start at 1-2 sprays per day and very gradually work up to 3-5 sprays once or twice daily. A tip for adults who develop headaches with wine, it is very likely that you are sensitive to sulfites and the ... ..more

MTHFR C677T Mutation: Basic Protocol by Dr Lynch on February 24, 2012 in C677T MTHFR Mutations
Have one or two copies of the MTHFR C677T mutation? Don’t know what to do?

After working with 100′s of individuals with this defect, I’ve developed a protocol which may help a significant number of people.
I want to make it absolutely clear that while the MTHFR C677T mutation may be common across a number of individuals, the outcome of supplementing with various nutrients can vary tremendously due to other genetic defects, dietary and lifestyle choices and environmental exposures.

Some of ... ..more

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#MTHFR #Lithium
Lithium has been known for years to be useful for #bipolar disorder. Despite all that is known about lithium and its impact on biochemical pathways, no one has defined the mechanism by which lithium has its impact on bipolar disorder. It is likely to be an effect on multiple pathways. There are a number of enzymes in the body that are known to be impacted and inhibited by lithium.

Lithium comes together with methylation at #COMT, the enzyme catechol-o-methyl-transferase. COMT breaks down #dopamine and #norepinephrine. Dopamine is a critical #neurotransmitter for motivation, focus and attention, among other functions ... ..more

Annonymous

DOES RED WINE GIVE YOU A HEADACHE?

  4 years, 1 month ago

http://www.thekitchn.com/su...

Red Wine contains RESERVATROL which is GOOD, but the headache is not.
Although it is NOT likely the cause of a headache, there is a trick for getting the sulfite from the potassium metabolite out of your red wine. The free sulfites in wine can dissipate into the air. The simplest way to encourage sulfites to leave your wine is to vigorously splash the wine around.
http://blog.eckraus.com/blo...
The “Headache” associated with red wine likely comes from the HISTAMINES, TANNINS and ALCOHOL in the red wine not the sulfites.

RESVERATROL and CANCER ... ..more

1) Let's treat all this stuff now! By and large, #supplements are probably some of the safest treatments you will ever find, particularly when one considers the side effects associated with most prescription medicines. However, every single thing that you take has benefits and drawbacks. Simply stated, this means that supplements should be treated as medication. When you consider that many of the #methylation defects require any number of vitamins, enzymes, and co-factors to work more efficiently, these replacements have a crucial purpose. Since #methylation is instrumental in so many reactions, from proper #immune system function and making new ... ..more