The MTHFR gene provides instructions for making an enzyme called methylenetetrahydrofolate reductase. This enzyme plays a role in processing amino acids, the building blocks of proteins. Methylenetetrahydrofolate reductase is important for a chemical reaction involving forms of the B-vitamin folate (also called folic acid or vitamin B9). Specifically, this enzyme converts 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. This reaction is required for the multistep process that converts the amino acid homocysteine to another amino acid, methionine. The body uses methionine to make proteins and other important compounds.
How are changes in the MTHFR gene related to health conditions?
homocystinuria - caused by mutations ... ..more
ME/CFS patients are notoriously very sensitive to medicines and supplements. It’s common to have adverse reactions, or to only be able to tolerate small doses.
Newbies are especially prone to taking too large of doses or going too fast. The following explains how to manage such sensitivity.
Start Low and Go Slow
Whenever you start a new medicine or supplement, it is suggested to practice Start Low and Go Slow.
This means starting with very small doses, much less than a normal dose, such as 1/8 of pill. That way, if you're going ... ..more
Lithium has been known for years to be useful for #bipolar disorder. Despite all that is known about lithium and its impact on biochemical pathways, no one has defined the mechanism by which lithium has its impact on bipolar disorder. It is likely to be an effect on multiple pathways. There are a number of enzymes in the body that are known to be impacted and inhibited by lithium.
Lithium comes together with methylation at #COMT, the enzyme catechol-o-methyl-transferase. COMT breaks down #dopamine and #norepinephrine. Dopamine is a critical #neurotransmitter for motivation, focus and attention, among other functions ... ..more
Epigenetics is the study of how the environment and/or methylation pathway influences gene function and gene expression. Methylation is the biochemical community that your DNA resides within and which substantially impacts health and illness. Epigenetics is multifactorial and evaluates the environmental impact of diet, supplementation, infection, stressors, and medical treatment as well as pollution and other toxic exposures on health status and disease outcomes.
One of the most intriguing aspects of this evolving field of science is the fact that many other issues impact genetic expression without actually altering the genetic configuration.
In the early 1990’s, Duke University ... ..more