“ #23andme currently only tests for THREE mutations in these genes. So, even if 23andme says you are normal for all three mutations, you could still have a harmful mutation somewhere else in one of these genes. Any harmful mutation means a person has Hereditary Breast/ #OvarianCancer Syndrome.
The three mutations 23andme tests for are found mostly in Ashkenazi (Eastern European) Jews. It just happens that these three mutations are easy to test for and are well-studied.
As a general rule, you are hoping NOT to see DI as the genotype at any of your #BRCA1 and #BRCA2 locations. Genotype DI ... ..more
Introduction to The Vagus Nerve
In people with fatigue, food sensitivities, anxiety and gut problems, brain fog and depersonalization, the vagus nerve is almost always at play. These people have lower vagal tone, which means a lower ability of the vagus nerve to activate.
The only question is what aspect of the vagus nerve is malfunctioning and how much the vagus nerve is a problem vs. other aspects of your biology.
The vagus nerve is part of the parasympathetic nervous system, referred to as the rest and digest system. It’s not the only nerve ... ..more
VDR Taq has a minor allele (MAF) of "G":
Here are some studies that reference VDR Taq (rs731236):
"We observed that women with GG (rs731236), ... were characterized by a significant correlation between vitamin D vs testosterone concentration and FAI value. We found a significant correlation between testosterone level and FAI vs vitamin D concentration in men with heterozygote AG in the rs731236 polymorphism"
"The VDR polymorphism, TaqI (rs731236), was associated with a 26 % risk reduction (TT vs. CC, OR 0.74)"
All ... ..more
The Raw Data you receive from 23andMe can be translated by Livewello for a 1-time fee of $19:95. LiveWello is unique because it gives users much more than just a 900 SNP Gene report: LiveWello will give you your report for 600,000 SNPs, AND attaches 11 resources for learning to each Gene.
Updates are FREE for Livewello users: Free updates are crucial as it allows users get their results for new SNPs when 23andMe adds new SNPS to your raw data during their Chip updates. It is also crucial for when new research is added to information about ... ..more
You probably have done your Gene Test for a variety of reasons that may not have included your health. Did you know that your Gene results contain information about mutations that research has associated with certain health issues? This information can include your potential risk for certain health conditions. Of course, we always advise that any information our software provides for you is discussed with your Doctor but it is important to maximize the information in your Gene results. Read: Methylation: Why It Matters For Your Immunity, Inflammation & More
6 Ways A DNA Test Can Help You Optimize Your Diet
Matching Genes and Vitamins. A Personalized Plan May Be in Your Future
Why would you need to run a Genetics test?
LiveWello is unique because it gives you much more than just a Gene report: The Livewello Gene App will give you Gene reports for 600,000 SNPs and conveniently attaches 12 resources for learning to each Gene. The App also offers free updates that reflect your results when 23andMe adds more SNPs to your raw data. The reason for this feature, is that we believe that people should have information for all the Genes in their Raw Data not just some of them. That way, you and your Heallthcare Practitioner can have the benefit of all this information when creating your treatment plan. Basically, as long as a SNP is in your Raw Data with rsID and Minor Allele, the App will generate your Gene Report for it.
So, how does the Livewello App work ?
1) Download your Raw Data from 23andMe, Ancestry.com or FTDNA etc. Save it to your desktop.
2) Go to the home page at: https://livewello.com/genetics
On that page, you can learn more about our genetics tools. Then, click the "Get Started" button to upload your raw data and pay the 1-time fee of 19:95. The raw data file you upload into the App should not be altered in any way. i.e. Do not edit the file name, file format or contents.
3) Livewello currently gives you unlimited Health reports for about 600,000 SNPs in your Raw Data. Once you’re done with uploading your raw data, you can start generating your Health Reports with these free tools:
a) The Gene Library is searchable and has thousands of FREE Health Reports you will find helpful and can download: https://livewello.com/snps/...
It is designed to give your health reports on Genes that Research Studies have associated with your health issues and Diagnosis. Share your reports with your Doctor. These Gene Reports could be good indicators that your Doctor may need to order further lab/diagnostic testing. As a Livewello Gene App user, you can install as many Gene Reports as you'd like. There is no limit!
b) The GWAS Health Conditions Tool
If you don’t see Gene Reports about your health issues in the Gene Library, use this tool:
It will give you health reports on Genes that Research Studies have associated with your health issues and Diagnosis: https://livewello.com/gwas
DIRECTIONS FOR THE GWAS Health Conditions FEATURE
To use the GWAS Health Conditions Tool go to https://livewello.com/gwas
i. Simply enter the health condition's name to see if any Genome-wide studies have been done on that condition. If studies exist, as you type, results will come up. Click on the result that matches your search.
ii. Click on "copy to SNP sandbox" and
iii. Click "build template" and "view report" to generate a report for yourself.
c) The SNP Sandbox Tool Use it to create customized Gene Reports based on any Gene or SNP names you choose to have in it. How-To Video: http://vimeo.com/103512972
EXAMPLES: YASKO'S NUTRIGENOMIC SNPs: https://livewello.com/snps/...
MTHFR Gene SNPs ... ..more
You have been diagnosed with a chronic health condition. Your genetic information will help you determine which genes or biochemical pathways were altered to result in that health condition. Getting to the root cause, will help facilitate recovery by tailoring any treatment plans and lifestyle changes your Doctor recommends specifically to your body.
Several members of your family live with one or several chronic health issues. Genetic information will help your family uncover the inherited Gene sequence patterns that contribute to the chronic illnesses plaguing them.
You plan to have a baby: Research is implicating certain genetic mutations in a ... ..more
A Standard Gene Report with information looks like this: https://livewello.com/snps/... This sample contains some useful info worth sharing with your Doctor.
1) When your Gene report is created, click the Gene itself (or the "i" icon in a Template). Livewello will link 12 Learning Resources directly to each of the Genes in your report. They are: Medline, GHR, Google Scholar, dbSNP, Ensembl, Wiki Genes, SNPedia Wiki Genes, Malacards and PubMed. If the info is not readily available, re-enter your gene name or health condition into that resource's search box to check if any further information is ... ..more
Trying to find your results on the BRCA Genes tested on by 23andMe? Here's an easy way to check your BRCA1/BRC2 results:
23andme currently only tests for THREE mutations in these genes. So, even if 23andme says you are normal for all three mutations, you could still have a harmful mutation somewhere else in one of these genes. Any harmful mutation means a person has Hereditary Breast/ Ovarian Cancer Syndrome.
The three mutations 23andme tests for are found mostly in Ashkenazi (Eastern European) Jews. It just happens that these three mutations are easy to test for and are ... ..more
PCOS or a genetic defect called Congenital Adrenal Hyperplasia Late on set. Sufferers may need these tests:
- OH - Pregnenolone,
-11 Deoxycortisol ,
-Cortisol (plasma) ( all of these are tested before 8 -8:30 AM).
-Free and total Testosterone,
-Aldosterone/Renin ratio, .
- A saliva cortisol test ( NeuroScience)
Get thyroid tests:
FREE T4 ,
TSH and all antibodies
Perhaps about half of PCOS women carry a CAH gene defect that no one tests for that can be fixed.
Visit Caresfoundation.org to get info. ..more
A health village is a group of people involved in your health and wellbeing. They can be family members, friends, teachers, mentors, neighbors and of course your healthcare practitioners. Once you identify them, consider creating a health village by getting a free livewello health acc at:
Then, add each of these people as your health village members. . With your permission, anyone who is your health village member can add/edit supplements, medications etc. This is helpful if for example, your Dr is a member of your health village.
Make sure you add other important information about your ... ..more
Blank or missing SNPs on your #Livewello report could be due to any of the following:
1) The raw data was prepared by a genotype chip that did not contain those missing SNPs. For example In Novenber 2013, 23andMe changed the chip they use in processing genetic raw data. Even though the #LiveWello App still works with the old Chip(s), the number of SNPs on the current V4 Chip decreased from 9000,000 to 600,000 SNPs. This decrease in reported SNPs, affects anyone that returned their test kit as of Nov/Dec 2013. Since Livewello can only generate ... ..more
By Helen Janneson Bense
A1298C single nucleotide polymorphism (SNP) affects the enzyme known as 5,10 MethyleneTetraHydroFolate Reductase (MTHFR). This polymorphism involves a down regulation of the MTHFR enzyme, responsible for the backwards reaction of the folate cycle, where 5-methylfolate (5MTHF) is converted into tetrahydrofolate (THF). This reaction is most important for the production of BH4 – tetrahydrobiopterin. Each turn of the folate cycle and conversion of 5MTHF to THF produces 1 molecule of BH4. In heterozygous and homozygous states, enzyme activity will be compromised by
approximately 30% and 70% respectively.
Functions of BH4
Cofactor for all three isotypes of nitric ... ..more
Functional medicine testing involves laboratory tests for biochemical and nutrient imbalances. Testing is individualized for each patient, based on their symptoms and medical history.
“We can also test for imbalances in other areas that give us specific information to create a personalized treatment plan for each patient,” says Dr. Young. Examples include:
Detoxification and biotransformation imbalances
Underlying causes of inflammation
Digestive and absorptive imbalances
Imbalances in gut microbiota
Genetic mutations like MTHFR that influence methylation pathways
8 Factors that Affect Your Methylation Process
--Genetics – Like an estimated 20 percent of us, you could be genetically predisposed to high homocysteine
--Poor diet – The word “folate” comes from “foliage.” You need to eat plenty of leafy greens, beans, fruit, and whole grains to get adequate levels of vitamins B6 and B12, betaine, and folate. Egg yolks, meat, liver, and oily fish are the main dietary sources of vitamin B12 — so long-term vegan diets can be a problem. Plus, certain compounds can raise levels of homocysteine and deplete the B vitamins. These include excess animal protein, sugar, saturated fat ... ..more