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MTHFR and L-METHYL FOLATE… Some Basic Information By Carol Savage M.D.

If you have the MTHFR Gene Mutations C677T and or A1298C and are already taking some L-Methyl Folate [5-MTHF] and Vitamin B12 you might also consider the following:

FOOD Eat plenty of Green Vegetables and beans to get some Dihydrofolate [DHF] and Vitamin B2 [Riboflavin] and many other naturally occurring minerals and vitamins that the body needs etc.

DIHYDROFOLATE [DHF] Dihydrofolate is needed to provide the earlier FOLATE PATHWAYS [the reactions that occur prior to the MTHFR enzyme] with the kinds of folates that they need in order ... ..more

COMT, GAD, MAOA/B and addressing methylation too soon can definitely cause neuro-psych issues, but it all comes back to methyl pooling. SNPs in these genes can also contribute: ACE, DAO, MTHFR (e.g., A1298C). Homozygous or 'AA' results for COMT V158M is particularly associated with anxiety & startle response. Quite a few SNPs & quite a few medical conditions can contribute to anxiety, of course (e.g., gut health & bacteria resulting in toxin exposure).

For brain fog / concentration issues, follow up on SNPs affecting ammonia (such as NOS gene, etc.) & BH4 levels (DHPR gene, etc.), also.

With anxiety as a chief ... ..more

5 “Healthy” Foods That Aren’t
January 15, 2014 by Erin Ter Beest

In a world of competing health claims, it’s hard to know what foods are really nourishing and health-promoting. Sometimes it’s even hard to tell whether or not something is really food or just a “food-like substance!” While the occasional #junk food isn’t going to kill you (and stressing out about completely avoiding it might actually do more damage than the occasional junk food itself), there are many “health” foods that have made their way into our diets regularly that are doing serious damage to ... ..more

1. Start eating 'clean'. Organic, non-GMO home made meals should become a priority. Eliminating #gluten and dairy to relieve your body from the burden of processing them should also begin.

2. Avoid taking any extra Folic Acid. There is already a lot of it in the nation's food supply, as it is added to [fortified] to many processed foods. If a person has the #MTHFR mutations then #L-Methyl Folate is the better choice. Choose this #supplement carefully.
Folic Acid will get turned into #Dihydrofolate and will be all gone, except for any more you may eat due to ... ..more

Julie Matthews, Author Nourishing Hope: Benefits range dramatically from child to child. Many parents report that their children make wonderful gains in language when starting a special diet, such as gluten-free casein-free – it may be an increase in words, speaking in sentences, or back and forth conversation. Some children make gains in behavior, a reduction in irritability or tantrums, or less hyperactivity. Other children have improvements in the quality of life, relief of digestive upset, fewer colds and infections, and are happier and healthier. While benefits differ, my experience as a Certified Nutrition Consultant specializing in autism for the past ... ..more

Lab Tests indicating a need to decrease #Calcium :
Elevated calcium relative to magnesium on a urine essential element test
Elevated calcium relative to magnesium on a red blood cell element test
Stims

#Supplements to help address high Calcium:
MitoForce Compounded Supplement
CoEnzyme Q10 Fatigue & Muscle Support Spray
GSH Capsules
Magnesium
Chamomile
Boswellia -Ayur Boswellia Serrata
Vinpocetine
Zinc
Paradex
Don Quai - Max V
Air Power
Black Cohosh
Prevagen 5mg or less ..more

Wow. What a thread! My serum B6 was a bit over ref range. My OAT showed it to be low. So my doctor thinks I'm not processing or absorbing it. She started me on P5P, but I have to spread my 33 mg of it throughout the day, or else I get jitters and tingly extremities. I'm not sure my OAT was interpreted optimally. My mag RBC was 5.5 before I recently increased supplementation. I know I have some kind of source of lack with zinc, because starting that cured my chronic insomnia. I have brain inflammation ... ..more

Annonymous

What is the Methionine Cycle ?

  3 years, 10 months ago

The Methionine Cycle is the major work tag (methyl donor) manufacturer. SAMe has over 400 functions in the community. Also serves as the main route through to liver & Waste cycle.

Methionine (SAM) Cycle AKA “SAM’s Corporation,” As SAMe has over 400 known methylation reactions, SAM’s Corporation is the chief work tag producer. It’s also where most of the action occurs since it contains the major thoroughfare to the liver (CBS & transsulfuration). While this often works to its’ advantage, it can also pose a safety risk since failure along this route may result in calamity (see Waste Facility ... ..more

Folic ACID will get turned into Dihydrofolate and will be all gone... except for any more you may eat due to eating many fortified cereals and bread products.

A little Folic ACID will not be a problem. The problems occur when the amount of Folic ACID outweighs the availability of L-Methyl Folate regarding the BRAIN since Folic ACID blocks up the #L-Methyl Folate [ #5-MTHF ] #Folate Receptor Alpha receptors and prevents the real thing [5-MTHF] from getting into the brain.

The rest of the body doesn't suffer from too much #Folic ACID....only the brain.
Folic ACID is synthetic ... ..more

#bloodsugar #diabetes diet #glaucoma #glucose #insulin #vitaminc
Diabetes and Glaucoma: A New Perspective

A study at the University of Michigan found people with diabetes have a 35% higher chance of having Glaucoma than people who do not. The study went on to say the reason for the higher rates of glaucoma in diabetics is “unknown.” My purpose for writing this article is to explain the nutritional reasons that diabetes and glaucoma often go hand in hand.

Before going further, let me state this very clearly: The purpose of this article is to provide education. Both diabetes and glaucoma are serious ... ..more

The recommendations to work on CBS is b6 active form p5p and molybdenum to balance copper and zinc and help break down excess sulfates. You can get some sulfate strips these ones http://www.amazon.com/gp/aw.... You want to get your urine sulfates down to at least 800 preferably 400 before adding in methylfolate and methylb12. ..more

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Annonymous

How does Methylation influence mood ?

  3 years, 9 months ago


It is important to understand the basics of methylation, and although a more detailed study of #methylation chemistry may be interesting, for our needs, it is not really necessary to study it here as it will only serve to confuse matters, so only the most important aspects will be considered.

Put simply, the methylation process makes #neurotransmitters (mood building blocks), and the issue of a person being an under or over methylator can be confusing, because there is contradiction between the various sources of information on the methylation process. For our purposes, we'll say that an over methylator is ... ..more

Elevated calcium relative to magnesium on a urine essential element test
Elevated calcium relative to magnesium on a red blood cell element test
Stims

Supports to help address high Calcium:
MitoForce Compounded Supplement
CoEnzyme Q10 Fatigue & Muscle Support Spray
GSH Capsules
Magnesium (Low dose in MetalAway, MTR/MTRR/SUOX and MitoForce)
Chamomile
Boswellia -Ayur Boswellia Serrata (In Inflammation compound-coming)
Vinpocetine
Zinc (Low dose In NaturoMycin Spray, SeroMood and PeptiMycin)
Paradex (In NaturoMycin Caps)
Don Quai - Max V
Air Power
Black Cohosh
Prevagen 5mg or less ..more

MAO-A (Monoamine oxidase A) is a critical enzyme involved in breaking down important neurotransmitters such as serotonin, norepinephrine, and dopamine. While a homozygous (+/+) mutation is very common, prolonged periods of stress, violence, or trauma can lead to epigenetic changes that further decrease enzyme activity. On the table above, males only have one allele since the gene is inherited through from their mother since it is located on the X chromosome.
Males are more likely to have this mutation, represented on the table as homozygous (+). Only females can be heterozygous (+/-) for this mutation.

When a (+/+) MAO-A mutation is combined with a ... ..more

Annonymous

What does a CBS Gene Mutation mean ?

  3 years, 10 months ago

CBS (cystathionine beta synthase) catalyzes the first step of the transsulfuration pathway, from homocysteine to cystathionine. Dr. Yasko considers addressing CBS mutations as first priority aside from addressing the gut.
This enzyme converts homocysteine to cystathionine. In a separate reaction, cystathionine is then converted to cysteine which in turn goes to taurine or glutathione among other things.

CBS defects are actually upregulations. This means the enzyme works too fast. Therefore, it is common to see low levels of cystathionine and homocysteine since there is a rapid conversion to taurine. This leads to high levels of taurine and ammonia.

The upregulation ... ..more

Annonymous

What is Sympathetic Dominance

  3 years, 9 months ago

#Sympathetic Nervous System “Fight or flight” or “Type A’s”
There are 3 basic #SNS Dominant subtypes: Basic, Extreme, & Inefficient SNS Dominant types. The following is a summary of the average SNS Dominant types.
Personality traits vary widely in this group depending on whether they are more analytical vs. emotional. For instance, more emotionally based SNS Dominants are likely to be more volatile and “nervous” whereas the more analytical type does not. 
 


The sympathetic nervous system (SNS) activates the glands and organs that defend the body against attack, whether it is running from a saber toothed tiger or you are struggling with a dreadful job and difficult boss. It is called the fight or flight system and once activated, it directs more blood to the muscles, #adrenals and the brain yet away from the digestive organs and skin. The adrenals pump out #epinephrine while the sympathetic nerve endings throughout the body release #norepinephrine . This system is #catabolic , which simply means that energy is used to prepare for defense, rather than for nourishment, healing, or waste removal. #Sympathetic activity triggers the thyroid and adrenal glands to provide extra energy for fighting or running away. The heart rate and blood pressure also increase, just as the blood flow to the digestive system and kidneys decreases. This process is largely due to the intensified release of stimulating chemicals, known as #neurotransmitters #epinephrine and #norepinephrine . While this activity is critical for survival, those who have chronic activation of the SNS often develop #anxiety, #insomnia , heart racing or disease (heart failure), and adrenal #fatigue . They also have “goose bumps” more frequently than other types and tend to do best in warmer weather. 
 
A Sympathetic Dominant Nervous System often leads to significant gastro-intestinal issues due to the poor #digestion of meats and fats. These folks often feel as though food "sits like a rock in my gut". Due to the rising levels of Norepinephrine (the body’s flight or fight neurotransmitter), digestion shuts down to reserve precious resources for survival. Chronic activation can lead many to feel agitated, jittery, wired, & restless as well as prone to sleep disturbances and anxiety. They may also experience the vicious cycle of the “Wired but tired” sensation when eating an inappropriate diet or taking the wrong supplements, which in their case, is filled with sweets and other junk foods or heavy proteins. When a dysfunctional sympathetic nervous system reigns supreme, one may experience anxiety, stress, or feelings of panic, which should normally only occur in response to a perceived threat. Subsequently, they may overreact to even the mildest of daily troubles. 



These individuals often start out thin and active yet poor diets—usually filled with sweets and starchy carbs often lead to later weight gain. When busy or stressed, they frequently forget to eat regularly, if at all. They are often pale, do not tolerate cold weather and tend to have colder hands & feet. Such individuals are often impatient and easily frustrated or angered, yet it appears to quickly pass. They often make for volatile partners and bosses, in that they frequently explode; yet minutes later have already moved on. They are also frequently viewed as “intense,” “aloof,” or “bold,” and have a tendency of “sticking their foot in their mouths” by being too aggressive or forward. Nevertheless, #genetic & environmental factors influence this area considerably.


They are also very driven, ambitious, and motivated people who may excel in academics or in high energy vocations that require multi tasking and social interaction. Many also enjoy a stimulating debate or confrontation (attorneys, politicians, generals). When healthy ... ..more

You wanna work on cbs first because it's an upregulation when you start adding methylfolate and methylb12 and you don't have cbs under control all of the folate and b12 will used up down the cbs pathway instead of being recycled in the methylation pathway. It's a kind of a big balancing act. But once you start finding the right balance and getting better you will start to see the positives. The big ones I use for cbs is b6 active form p5p and molybdenum to balance copper and zinc and help break down excess sulfates. You ... ..more

Annonymous

What is the Krebs Cycle?

  3 years, 10 months ago

The Energy or Citric Acid Cycle:
The Krebs cycle, also called the citric acid cycle or the “Energy Cycle,” is a series of chemical reactions that convert food (sugar, protein, and fat) into energy (ATP). It is referred to as a cycle since it should always end where it began. This process occurs through three main stages within each cell:

1). Glycolysis, otherwise known as the breakdown of sugar, yields 2 molecules of ATP, 2 molecules of NADH, and two forms of pyruvate (6 forms of currency in all). This is actually a step that takes place before the energy ... ..more

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Julie Matthews, Author Nourishing Hope: Benefits range dramatically from child to child. Many parents report that their children make wonderful gains in language when starting a special diet, such as gluten-free casein-free – it may be an increase in words, speaking in sentences, or back and forth conversation. Some children make gains in behavior, a reduction in irritability or tantrums, or less hyperactivity. Other children have improvements in the quality of life, relief of digestive upset, fewer colds and infections, and are happier and healthier. While benefits differ, my experience as a Certified Nutrition Consultant specializing in autism for the past ... ..more